Pan-lab-SMART See the small and know the large

Research

Mainly using structural biology, biochemistry, physiology and other means, engaged in the study of the working mechanism and drug action mechanism of membrane proteins related to major diseases. At present, the research direction includes membrane proteins related to metabolic diseases and proteins related to tumor-immunity.

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2024

Author Correction: Structural biology and molecular pharmacology of voltage-gated ion channels
Author Correction: Structural biology and molecular pharmacology of voltage-gated ion channels
Jian Huang, Xiaojing Pan, Nieng Yan
Nature Reviews Molecular Cell Biology  ·  24 Sep 2024  ·  doi:10.1038/s41580-024-00786-0
Structural biology and molecular pharmacology of voltage-gated ion channels
Structural biology and molecular pharmacology of voltage-gated ion channels
Jian Huang, Xiaojing Pan, Nieng Yan
Nature Reviews Molecular Cell Biology  ·  05 Aug 2024  ·  doi:10.1038/s41580-024-00763-7
Structural basis for urate recognition and apigenin inhibition of human GLUT9
Structural basis for urate recognition and apigenin inhibition of human GLUT9
Zilin Shen, Li Xu, Tong Wu, Huan Wang, Qifan Wang, Xiaofei Ge, Fang Kong, Gaoxingyu Huang & Xiaojing Pan
Nature Communications  ·  12 Jun 2024  ·  doi:10.1038/s41467-024-49393-9
structural-biology transporters drug-discovery
Structural basis for urate recognition and apigenin inhibition of human GLUT9
Structural basis for urate recognition and apigenin inhibition of human GLUT9
Zilin Shen, Li Xu, Tong Wu, Huan Wang, Qifan Wang, Xiaofei Ge, Fang Kong, Gaoxingyu Huang, Xiaojing Pan
Nature Communications  ·  12 Jun 2024  ·  doi:10.1038/s41467-024-49420-9

2022

High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV
High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV
Gaoxingyu Huang, Dongliang Liu, Weipeng Wang, Qiurong Wu, Jiaofeng Chen, Xiaojing Pan, Huaizong Shen, Nieng Yan
Cell Reports  ·  01 Apr 2022  ·  doi:10.1016/j.celrep.2022.110735

2021

Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na sub v sub 1.5 by the Antiarrhythmic Drug Quinidine
Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine**
Zhangqiang Li, Xueqin Jin, Tong Wu, Gaoxingyu Huang, Kun Wu, Jianlin Lei, Xiaojing Pan, Nieng Yan
Angewandte Chemie International Edition  ·  06 Apr 2021  ·  doi:10.1002/anie.202102196
Comparative structural analysis of human Na sub v sub 1.1 and Na sub v sub 1.5 reveals mutational hotspots for sodium channelopathies
Comparative structural analysis of human Na v 1.1 and Na v 1.5 reveals mutational hotspots for sodium channelopathies
Xiaojing Pan, Zhangqiang Li, Xueqin Jin, Yanyu Zhao, Gaoxingyu Huang, …, Zilin Shen, Yong Cao, Mengqiu Dong, Jianlin Lei, Nieng Yan
Proceedings of the National Academy of Sciences  ·  12 Mar 2021  ·  doi:10.1073/pnas.2100066118
Structure of human Na sub v sub 1.5 reveals the fast inactivation-related segments as a mutational hotspot for the Long QT Syndrome
Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the Long QT Syndrome
Zhangqiang Li, Xueqin Jin, Tong Wu, Xin Zhao, Weipeng Wang, Jianlin Lei, Xiaojing Pan, Nieng Yan
Cold Spring Harbor Laboratory  ·  07 Feb 2021  ·  doi:10.1101/2021.02.06.430010
Structural determination of human Nav1.4 and Nav1.7 using single particle cryo-electron microscopy
Structural determination of human Nav1.4 and Nav1.7 using single particle cryo-electron microscopy
Methods in Enzymology  ·  01 Jan 2021  ·  doi:10.1016/bs.mie.2021.03.010

2020

Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence
Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence
Ximin Chi, Xueqin Jin, Yun Chen, Xiaoli Lu, Xinyu Tu, …, Jianlin Lei, Jing Huang, Zhuo Huang, Qiang Zhou, Xiaojing Pan
Cell Discovery  ·  10 Aug 2020  ·  doi:10.1038/s41421-020-00193-7
Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na sup sup channels in nanodisc
Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na + channels in nanodisc
Shuai Gao, William C. Valinsky, Nguyen Cam On, Patrick R. Houlihan, Qian Qu, Lei Liu, Xiaojing Pan, David E. Clapham, Nieng Yan
Proceedings of the National Academy of Sciences  ·  08 Jun 2020  ·  doi:10.1073/pnas.1922903117

2019

Cryo-EM structures of apo and antagonist-bound human Cav3.1
Cryo-EM structures of apo and antagonist-bound human Cav3.1
Yanyu Zhao, Gaoxingyu Huang, Qiurong Wu, Kun Wu, Ruiqi Li, Jianlin Lei, Xiaojing Pan, Nieng Yan
Nature  ·  25 Nov 2019  ·  doi:10.1038/s41586-019-1801-3
Molecular basis for pore blockade of human Na sup sup channel Na sub v sub 1.2 by the μ-conotoxin KIIIA
Molecular basis for pore blockade of human Na + channel Na v 1.2 by the μ-conotoxin KIIIA
Xiaojing Pan, Zhangqiang Li, Xiaoshuang Huang, Gaoxingyu Huang, Shuai Gao, Huaizong Shen, Lei Liu, Jianlin Lei, Nieng Yan
Science  ·  22 Mar 2019  ·  doi:10.1126/science.aaw2999

2018

Structure of the human voltage-gated sodium channel Na sub v sub 1.4 in complex with β1
Structure of the human voltage-gated sodium channel Na v 1.4 in complex with β1
Xiaojing Pan, Zhangqiang Li, Qiang Zhou, Huaizong Shen, Kun Wu, …, Jianlin Lei, Wei Xiong, Haipeng Gong, Bailong Xiao, Nieng Yan
Science  ·  19 Oct 2018  ·  doi:10.1126/science.aau2486
Structural basis for the modulation of voltage-gated sodium channels by animal toxins
Structural basis for the modulation of voltage-gated sodium channels by animal toxins
Huaizong Shen, Zhangqiang Li, Yan Jiang, Xiaojing Pan, Jianping Wu, …, Yanni K. Y. Chin, Jianlin Lei, Qiang Zhou, Glenn F. King, Nieng Yan
Science  ·  19 Oct 2018  ·  doi:10.1126/science.aau2596