We are Pan lab
We are Pan lab from IBABI (Institute of Bio-Architecture and Bio-Interaction of
SMART),
focusing on single particle Cryo-EM.
About Our Research
Our lab specializes in **single-particle Cryo-EM** to determine high-resolution structures of membrane proteins, unraveling their working mechanisms and drug action principles. We combine structural biology with **biochemistry, physiology, and medicinal chemistry** to tackle key questions in disease biology.
**Research Directions:**
- Metabolic disease membrane proteins — structure-based drug discovery
- Tumor-immune related proteins — structural basis for immunotherapy
Representative Publications
Structural biology and molecular pharmacology of voltage-gated ion channels
Nature Reviews Molecular Cell Biology
·
05 Aug 2024
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doi:10.1038/s41580-024-00763-7
Structural basis for urate recognition and apigenin inhibition of human GLUT9
Nature Communications
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12 Jun 2024
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doi:10.1038/s41467-024-49420-9
Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA
Science
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22 Mar 2019
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doi:10.1126/science.aaw2999
Structural basis for the modulation of voltage-gated sodium channels by animal toxins
Science
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19 Oct 2018
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doi:10.1126/science.aau2596